Osteoarthritis: new insights.

Patellofemoral osteoarthritis: new insights into a neglected disease

New insights in pathophysiology of contact hypersensitivity: From transgenic mice to human pathology

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Genetic contribution to osteoarthritis development: current state of evidence

PURPOSE OF REVIEW Powerful association studies have identified a number of genetic signals that can be confidently judged as associated with osteoarthritis. Efforts have continued to discover new loci, whilst functional studies are being applied to assess which genes are the likely targets of the risk-conferring alleles. The study of epigenetics has highlighted an interaction between osteoarthr...

Osteoarthritis: new insights. Part 1: the disease and its risk factors.

Osteoarthritis is the most common form of arthritis, affecting millions of people in the United States. It is a complex disease whose etiology bridges biomechanics and biochemistry. Evidence is growing for the role of systemic factors (such as genetics, dietary intake, estrogen use, and bone density) and of local biomechanical factors (such as muscle weakness, obesity, and joint laxity). These ...

Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18–20 April 2004

The Kennedy Institute of Rheumatology Symposium ‘Molecular Approaches to Osteoarthritis’ was held at Imperial College London on 18–20 April 2004. It encompassed current research into the molecular processes in cartilage underlying the initiation and progression of osteoarthritis (OA). The symposium also examined the potential impact on the field of new methodologies such as transcriptional prof...

A Critical Review of Proximal Fibular Osteotomy for Knee Osteoarthritis

The surgical management of Knee Osteoarthritis (KOA), so far, mainly revolved around arthroscopic procedures,arthroplasty (total: TKA and unicompartmental: UKA) or high tibial osteotomy (HTO). Recently, another minimallyinvasive surgical treatment of proximal fibular osteotomy (PFO) has been proposed for the management of KOA. ThePFO has been found to be useful in the manageme...